Research Of Clinical Pathology On The Prognostic Factors Of Gastrointestinal Stromal Tumor

Objective: To investigate the prognostic factor affecting gastrointestinal stromal tumor(GIST), and evaluate the rationality of the new way of Flecther classification, which is used to judge the prognostic biological behavior, so as to give evidence on clinical therapy and prognostic analysis on GIST.Materials and Methods: â‘ 106 cases of tumor of mesenchymal tissue in digestive canal from year of 1998 to 2004 in Shanxi Provincial Tumour Hospital were collected, and the section ,the staining of HE and the staining of immunity (Envision method) were done on all examples again , the final diagnos were attained by histological morphous observation and immunity.â‘¡ Among these cases, 91 cases are finally diagnosed to be GIST with the age of the patients ranged from 19 to 75, averaged in 53, and 84% of the patients are more than 40 years old, male patients accounted as 43 cases,and female for 48 cases. Meanwhile, 3 cases were accompanied with canceration in digestive tube, 62 cases with canceration in gastrointestinal tract(8 cases in esophagus, 34 cases in stomach, 4 cases in dodecadactylon, 7 cases in jejunum, 4 cases in colon, 5 cases in rectum), 29 cases were out of gastrointestinal tract(12 cases in back peritoneum, 1 case in peritoneum, 13 cases in mesentery , 3 cases in epoploon); the diameter of the tumors are 1.6-42cm, among which, the diameter of the tumors are 0-2cm in 3 cases, and about 2-5cm in 21 cases, more than 5cm in 67cases. Tumors were totally cut by operation in 85 GIST cases, 6cases were given palliative operation and part diversion of lymphaden were found in 2 cases after operation. diversion were found before operation in 8 cases, among which, 3 as liver metastasis, 2 as abdominal cavity diversion, 1 as pulmonary metastasis diversion and 2 of peritoneum diversion. Follow-up materials are built for 51 cases of GIST(56%), and visiting time on patients was from 1 month to 72 months. â‘¢ Analyzing age, gender, size of tumors, number of karyokinesis, CD117, blooding, necrosis, location of tumors(inner or outside tumors of gastrointestinal tract), and the Flecther method as well.if the existence of statistical diffence ,calculating survival rate and drawing survival curve in Kaplan-Meier method, planning to practice the multi factor analysis of survival by using recurring cox model. Result: â‘ By using new Flecther method(in List l)to make classification in 51 cases of GIST Followed-up: 2 cases with the lowest invasion chanciness, 16 cases with low invasion chanciness, 63 cases with midrange invasion chanciness, 10 cases with high invasion chanciness. â‘¡Different age, gender, tumor bleeding, Tumor necrosis, tumor location, CD117 expression survival single factor analysis no difference(P>0.05), survival rate of the group with P<0.05...