Pharmacodynamic Research And Related Pathophysiological Mechanism Of FuKangPing In Prevention And Treatment Of Cervical Spondylotic Radiculopathy

Cervical spondylotic radiculopathy(CSR), which caused by outside factors, leads to obstacle of sense, locomotion and reverberation, and take spondylalgia as the cardinal clinical symptom. According to the Epidemiology Investigate, the adult sick rate of the Cervical Spondylosis is about 3.8-17.6% in China. Reckon the existing population, at least 5-10 million people are be attacked with CSR, which is about 60-70% in the total outbreak rate, is the highest incidence category among cervical spondylosis. Concerning the cervical spondylosis at the earliest stage concept in medical science field, mostly come from CSR, which can said as representative. It's wore that cervical spondylosis attack not only the old but also the younger because of the modern life. Therefore, it is an urgent task to further definite the pathophysiological mechanism of CSR. The research indicated that inflammatory mechanism has important function in CSR and the anti-inflammatory therapy has become an important intervention treatment. The pathophysiological mechanism of CSR is very complex. Previous studies have demonstrated that it related with many factors, such as leucocyte infiltration, cell factor and inflammatory, etc. At present, there is lack of the novel therapeutic efficacy yet. On the contrary, therapeusis of Traditional Chinese Medicine (TCM) have special treatment preponderance. FuKangPing is compound of four medicines such as cassia twig. My study was from different levels with the methods of biochemical assay, somatosensory evoked potential (SEP), immunohistochemistry, enzyme-linked immunosorbent assay, molecular biology, ect. So that it can provide the experiment proof for studying FuKangPing pharmacodynamic mechanism of curing CSR.Prat 1 Study on the protective action of FuKangPing on CSR and possible pharmacodynamic mechanism1.1 Effects of FuKangPing on CSR in rats Objective: To observe the effects of FuKangPing on ordinary locomotion, somatosensory evoked potential (SEP) and nerve transmit function of rat with...