Evaluate The Security And Feasibility Of Percutaneous Microwave Coagulation Therapy For Pulmonary Tumor In Rabbits

Objective The project is to evaluate the use of percutaneous microwave coagulation therapy for lung carcinoma of the rabbits. To optimize technical parameters and discuss PMCT security and feasibility by means of animal experiments.Methods To establish an animal model of lung tumors in 30 New Zealand rabbits by tissue clot suspension injection. The rabbits were divided into the three groups, which were considered appropriate for treatment. The control group received sham operation. The surgical A group and surgical B group were treated with PMCT in different technical parameters. The therapeutic efficacy was evaluated by survival time, CT, postmortem micro angiography, and histology. The animals were scanned with CT once a week to monitor tumor growth and the ablation effects periodically after therapy. At specified time point, one animal was sacrificed randomly for histologic. The untreated control rabbits and the treated rabbits were compared in terms of survival.Results The tumorigenic rate was 100%. Successful tumor growth was obtained at 86.7% of the implantation sites. The animals in the control group died of end-stage malignancy within 2 months (39.667±5.279days). The mean survival time of surgical A group and surgical B group were 62.167±4.355days and 61.667±4.457days. The incidence rate of pneumothorax after PMCT in control group, surgical A group and surgical B group were 33.3 %(2/6), 55.6 %(5/9) and 33.3%(3/9).Conclusion (1)the models of VX2 tumor transplantation in New Zealand rabbit lung which were established by tissue clot suspension injection was more suitable for the study of PMCT of lung tumors.(2) PMCT is a safe, effective and minimally invasive therapeutic option for the pulmonary carcinoma. (3)PMCT has emerged as an alternative for surgery in clinical oncology.