Establishing Animal Model Of Functional Pulmonary Lobectomy And Test Of Relative Data

Objective: Establishing animal model of functional pulmonary lobectomy (FPLT) by the target bronchus and lung bubbles were filled with emulsion of iodine oil and Pingyangmycin (PYM) and then target bronchus was occluded. And to evaluate the efficacy and safety of FPLT.Method: 18 healthy dogs were divided into three groups randomly, each 6. Group A: the target bronchus and lung bubbles were filled with emulsion of iodine oil and PYM and then target bronchus was occluded with Polymethylmethacrylate (PMMA). Group B: the target bronchus was only occluded with PMMA and Group C: pulmonary lobe was resected. Artery blood gas were measured at the time of pre-operation and post-operation immediately and then 1st, 2nd, 3rd and 4th week after operation respectively. Chest radiolography and histology and bacterial culture of tissue of target lung lobe were made after 4 weeks.Results: There was a significant difference in artery blood-gas among 3 groups pre-operation compared with post-operation immediately (P<0.01) and no difference (P<0.05) compared with 1st, 2nd, 3rd and 4th week after operation. It was showed that the atelectasis radiologically and fibrosis of target lung lobe histologically and no bacterium grew in target tissue the 4th week after operation. There were 3 cases of lung atelectasises but no pulmonary fibrosis in group B, one dog dead of wound infection after 4 days.Conclusions: FPLT might be obtained after the target bronchus and lung bubbles were filled with emulsion of iodine oil and PYM and then target bronchus were occluded with PMMA.FPLT is a microtrauma, safe and effective procedure and might partially replace the surgical pulmonary lobectomy in future.