Association Of The Vitamin D Receptor Gene Polymorphism With Delayed Rickets

Objective To explore the hereditary susceptibility of children to develop delayed rickets through studying the association of the vitamin D receptor gene starts codon (VDRSC) polymorphism with delayed rickets.Methods The diagnosis was based on clinical, biochemical and radiological data. The VDRSC genotypes of three groups were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results The significant difference was found in the frequencies distribution of VDRSC genotypes ( x ~2=13.184, P=0.010) and VDRSC alleles ( x ~2=10.305, P=0.006) among three group;The frequency of the FF genotype 56.7% in the patient group was significantly higher than that 21.7% in the control group(P< 0.00227) and that 22.9% in the vitamin D deficiency group(P<0.00625). Multiple logistic regression analysis showed that FF genotype had a higher risk of delayed rickets(0R=3. 120), indicating that FF genotype may be significantly associated with delayed rickets.Conclusion There is an association between the VDRSC polymorphism and delayed rickets, there is the possibility that the VDRSC polymorphism might be important in determining the hereditary susceptibility of children to develop delayed rickets.