Relativity Between Monocyte Chemcattractant Protein-1 -2518(A/G) Polymorphism And Type 2 Diabetes Mellitus

Objectives: To determine whether the Monocyte Chemcattractant Protein-1 (MCP-1) -2518(A/G) gene polymorphism was associated with type 2 diabetes mellitus in the north-west population of China.Method: 41 cases with normal control subjects and 57 cases with type 2 diabetes patients have taken fasting blood samples for measurements of plasma glucose, plasma lipids, insulin. MCP-1 genetype was determined by technique of PCR-RFLP, and investigated the association of MCP-1 polymorphism and type 2 diabetes mellitus.Results: In type 2 diabetes mellitus group, fasting blood glucose(FBG), waist-to-hip ratio(WHR), Systolic Blood Pressure(SBP), Diastolic Blood Pressure (DBP), Homeostasis Model Assessment index of insulin resistant (HOMA-IR) higher than normal control group, Insulin Sensitive Index(ISI) lower than normal control group. There were no significant differences in genotype frequencies and allele frequencies of MCP-1 gene between type 2 diabetes mellitus group and normal control group (P>0.05). Multivariate logistic regression analysis showedthat MCP-1 G allele was the protective factors of type 2 diabetes mellitus, while FBG, WHR, HOMA-IR, CHO were the risk factors of type 2 diabetes mellitus.Conclusion: The MCP-1 gene polymorphism genotype frequencies and allele frequencies of type 2 diabetes mellitus patients are not different from normal control, the MCP-1 gene polymorphism was not associated with type 2 diabetes mellitus. MCP-1 G allele was the protective factors of type 2 diabetes mellitus;FBG, WHR, HOMA-IR, CHO were the risk factors of type 2 diabetes mellitus.