| Objective: To study the correlation between ocular biometry and anisometropia, the factors which influence the development of myopia,and the relationship between the dominant eye and the eye with higher myopia among anisometropes;to investigate the binocular vision function in corrected anisometropes;to examine the relationship between vertical anisometropic spectacle correction and vertical fusional amplitudes in patients.Methods: The subjects come from the center of optometry and the laser operation center of our hospital, we conducted the pilot study before the formal examination. The self-designed Table for Survey of anisometropes was used in the questionnaire investigation and examination of the subjects. The collected data include: general material (name, sex, age, nationality), the history of eye-related diseases of parents and ametropia, patient's past history of eye diseases, ophthalmological examinations (the examinations of distant visual acuity include uncorrected, presenting and corrected visualacuity, cover-uncover test, ocular movement, stereoscopic visual acuity, conjunctiva, corneas, pupils, lens, the refraction, vitreous and retina, etc.)and the binocular vision function.The strabismus,opacity of refractictive media,fundus disease,ocular trauma and operation were excluded from the study.70 subjects who have anisometropia (^l.OD) average aged 19.16 + 5.6 years were randomly selected, 35 subjects without anisometropia (<1.0D) were recruited for the control group. For each subject refractive error and ocular biometry were measured,at the same time ,we also check the binocular vision function.The frequency statistics were used to describe the distribution of ocular biomery and ocular motor parameters. T-test and ANOVA were used to compare the differences of ocular biomery and ocular motor parameters's average between higher eye and lower eye of anisometrpes,and among different groups. Chi-square test was used to compare the significance of differences among the distributions of binocular vision function of different groups. Correlation analysis of the relationship between anisometropia and ocular biometry,vertical fusional amplitude and vertical anisometropia was done.Result:1. The difference of Ks,Kf,Averk for two eyes is almost same among different groups (F value is 0.11, 1.71,1.49;corresponding p value is 0.896,0.16 and 0.23) .2.The difference of AL, VT,AL/CR between higher eyes and lower eyes of anisometropia is increased by the severity of anisometropia.The difference is statistically different between control group and anisometropia group (F value is 94.845,99.146,8.708;p value is 0.000 );the difference of ACD and lens between two eyes isn't statistically among groups (F value is 0.619,0.96;corresponding p value is 0.54,0.38) .3.It is significant positive correlation between the degree of anisometropia and the differences of axial,vitreous thickness of two eyes ( p<0.001 ) .the anisometropia have no correlation with AveK,ACD and lens thickness (p>0.05) .4.Axial anisometropia account 88.6% versus compound anisometropia is 11.4% in lower anisometropia groups;Axial anisometropia account 77.1% versus compound anisometropia is 22.9% in moderate and strong anisometropia groups.5. Eye dominance was significantly associated with the higher mypoic eye(the coincident percent is 77.1% in lower anisometropia group,decreased to 62.9% in moderate and strong anisometropia groups.Dominant eyes and eyes with higher myopia were significantly related to the right eye in each group(right dominate eye is 70.5%, left eye is 29.5%).6. The prevalence rate of nomal for phoria of near distance is 65.7% in control group,42.9%in lower groups,and 37.1% in media anisometropia groups,it is statistically different among groups ( x 2=6.405, p<0.05);the rate for stereopsis is 91.4%,77.1%,54.3% to three groups, it is statistically different among groups(x2=12.863, p=0.002).7. The prevalence rate of nomal for phoria of far distance, AC/A among groups is not statistically different.( x 2=0.551,0.7647 , p=0.759, 0.382)8. The differences of NRA,PRA,AMP,FCC among groups isn't statistically different , F value is 1.499,2.276,2.745,3.276 and 2.465,0.365;corresponding p value is 0.228,0.108,0.069,0.042 and 0.090,0.695 o9. In patients exposed to greater than 1.0 diopters of vertical anisometropic spectacle correction,vertical fusional amplitudes measured 4.45 ± 1.50 prism diopters. Patients not exposed to anisometropic correction had vertical fusional amplitudes of 3.61 + 1.01 prism diopters (/=3.432,p=0.001) . Conclusion:1. Anisometropia is correlated with the unbalanced development of the axis between two eyes.2. Under the same gene, the development of myopia may be caused by the increased of vitreous length.;3. The dominant eye may develop before anisometropia, and myopic anisometropia may affect the choice of the dominant eye.4. The nomal prevalence of the stereopsis and the phoria of near distance is decreased with the increased of anisometropia,but other ocular motor parameters is normal among groups.5. Patients with vertical anisometropic correction have increased vertical fusional amplitudes. |
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