Study On Changes Of Adrenergic Receptors After High-level Spinal Cord Injury In Rats

The purpose of this study was to evaluate sensitivity changes in peripheral α₁-adrenergic receptor at chronic stage, to observe apoptosis of thoracic ganglia and expression of α (a₁, a₂) - adrenergic receptors in the spinal cord at different time points in a high-level spinal cord injury (SCI) rat model.We found that supersensitivity of peripheral ai-adrenergic receptors may be a contributing factor to the severe hypertension characteristic of autonomic dysreflexia, and that destruction and regeneretion of ganglia and synapse and changes of alpha-1, 2 adrenergic receptors express and ratio of alpha-1/ alpha -2 adrenergic receptors may be central factors contributing to spinal shock and autonomic dysreflexia after SCI.