A Clinical Observation Of NP In The Treatment Of Advanced Stage Non-small-cell Lung Cancer

Purpose: to observe the efficacy and toxicity of vinorelbine combined with cisplatin(NP regimen) in the treatment of advanced non-small-cell lung cancer(NSCLC). Methods: 42 patients with advanced NSCLC were confirmed by path-ology or cytology.There were 4 patients with lung adenocarcinoma,38 with squamous carcinoma.23 patients had stage â…¢diease and 19 patients had stage â…£.All patients had no prior chemotherapy.NVB were used 25mg per centiare on days 1 and days 8;DDP were used 60mg to 80 mg per centiare on days 1 to days 3.A Period includes 28 days.to evaluate the efficacy and toxicity after 2 periods at least. Results: Complete response was observed in 3 patients and partial response was observed in 15 patients.The overall response rate was 42.9%.The main tocicity was leucopenia and vomiting.The dose limiting toxicity was neutropenia that was observed in 83.3% of the patients(11.9% in grades â…¢and â…£).About 54.7% of the patients was observed vomitting . Conclusions: The results indicate NP regimen for advanced NSCLC is promise,and the toxicities are tolerable.