Clinical Study On The Role Of VEGF In The Pathogenesis Of Proliferative Vitreo-retinal Disorders

Objective: (1) To respectively compare the concentrations of vascular endothelial growth factor (VEGF) in aqueous humor and vitreous between patients with proliferative vitreoretinopathy (PVR), retinal vein occlusion (RVO) with vitreous hemorrhage, proliferative diabetic retinopathy (PDR), neovascular glaucoma (NVG) and control group, and analyze its changing regulation. (2) To discuss the role of VEGF in the pathogenesis of proliferative vitreo-retinal disorders. (3) To provide the theoretical basis for the prevention and treatment of proliferative vitreo-retinal disorders.Methods: The concentrations of VEGF of aqueous humor and vitreous respectively obtained from 49 eyes of 48 patients with PVR, RVO with vitreous hemorrhage, PDR or NVG who had received the treatment of vitrectomy were measured using enzyme-linked immunosobent assay (ELISA). As control, the concentrations of VEGF of aqueous humor and vitreous from 8 eyes of 8 normal people were measured with the same method.Results: (1) The mean x±s VEGF concentrations in aqueous humor and vitreous from patients with PVR, RVO, PDR, NVG and control group were [(314.35±129.32), (422.80±187.92)pg/ml], [(473.60±223.54),(965.75±520.34)pg/ml], [(595.26±371.66), (1182.15±957.53)pg/ml],[(3887.36±241.10), > 4500pg/ml], and [(75.50±7.45, (144.70±18.38)pg/ml] respectively. (2) The VEGF concentrations in aqueous humor and vitreous from patients with PVR, RVO, PDR and NVG were higher than that of control group (P<0.05). (3) The VEGF concentration of vitreous in each group was higher than that of aqueous humor (P<0.05). (4) Among all disorders, the VEGF...