Studies On An Absorbable Suture Which Is Made By Tendon In Tails Of Myocastor Coypus

The study on the absorbable suture is one of the most active domains on biomedicine macromolecule research. They had been used in medicine and veterinary widely. The purpose of this research is to manufacture a new style suture which has excellent biocompatibility, lower antigenicity, good degradability and absorbility. The following are the main content:1. the production of tendon suture and studies on physical properties of it: tendon suture was produced by fat and water removal tendon that was double fixing, etc. Then the length and diameter of sutures were measured and the tensile strength was calculated. Results showed that the length of 55 percent tendon was more than 20 cm and the diameter of 80 percent tendon was around 0.30—0.59 mm. The tensile strength of tendon sutures which were crosslinked by 2% concentration glutaraldehyde is the strongest. It is 275.43 N/mm that is ideal for the demand of wound healing.2. research on the cytotoxicity of the tendon suture: the suture materials and chicken embryo's fibroblasts were cultivated in vitro together. And the effect of the shape and proliferation of cells were observed. Results showed that this new style suture hadn't negative effect on cell's formation but active effect on proliferation of cells. So it has an excellent biocompatibility and is suitable for making medical suture.3. studies on the compatibility of the tendon suture: some experiments were done based on the cell toxicity test, they are urgent toxicity, pyrogenic reaction, skin stimulated and hemolytic test. Then their test datas were analyzed and evaluated according to ISO. These experiments had the negative outcomes. It showed that the tendon suture had good biocompatibility, and it is an ideal biology material for medicine.4. studies on antigenicity of tendon suture: a large amount of tendon suture solution were injected into rabbits by vein immunizing to study their immunological responses and reactions. And tendon suture solution, bovine's Hb and rabbit's Hb were infused into rabbits by subcutaneous , abdominal cavity and muscle immunizing. It was intended to study the degrees of antigenic activity. Inference can be drawn that there would unlikely emerge accidents in rabbits after infusion tendon suture solution.5. the reactions after implantation and research on the degradation property...