The Experimental Study Of Security Of Itraconazole For Tinea Capitis In Children

Tinea capitis is a common kind of superficial fungal infective disease in skin. Itraconazole taken orally is widely used to treat all kinds of fungal infections in adults in recent years with definite effects and lower side effects, however there is not adequate evidence for children(especially younger than 2 years). Nowadays it is widely accepted that it is not proved that itraconazole, terbinafine and fluconazole can be used in children properly. However tinea capitis especially kerion can not be cured only by external ointments without antifungal medicine in children. There are many reports that griseofulvin is the first choice for kerion,but it can hardly be used in children for its hepatic toxicity .The most urgent problem to solve now is to prove the security of itraconazole in children by animal experiment and then we can take use of it properly. And our experiment is to study the security of itraconazole(commercial name is sipirennuo) for tinea capitis in children. Take the experimental rats into 8 groups including 3 groups for therapeutic dose,3 groups for toxic dose and 2 groups for lethiferous dose, with 10 rats for each group and male and female for half. Measure the hepatic and renal function and the tissue biopsy after 4 weeks,8 weeks and 12 weeks of treatment with therapeutic dose. Take the blood specimen to measure the hepatic and renal function and the tissue biopsy after the active and motive abnormities called toxical manifestation such as posture changes, abnormal sound, uneasiness, quiet, thrill, ataxia, convulsion and so on with toxic dose. Measure the tissue biopsy after death with lethiferous dose. If no toxicity or death occur after the experiment of 12 weeks, measure the hepatic and renal function and the tissue biopsy. There was no rat which had the toxical manifestation such as active or motive abnormities and 3 rats died because of environment or others after the experiment of 12 weeks. In result 2.5% of the rats got slight hepatic enzymes increase, and 6.25% of the rats got slight fat degeneration for hepatic tissue specimens. Most of the rats with abmormal results occurred in the toxic and lethiferous group, and there was the increasing tendency with the increase of dose. There were no changes for renal function and tissue biopsy. From the experiment we can make the conclusions as followed: 1,Itraconazole of therapeutic dose can be used for tinea capitis in children including children younger than 2 years with high security without obvious hepatic and renal damage. 2 ,Itraconazole of overdose should be used under consideration ,because it can cause some hepatic side effects such as hepatic enzymes increase and fat degeneration. 3,Itraconazole can hardly affect the renal...