Experiment On The Mechanisms Of Pulmonary Edema Induced By Organophosphorous Pesticide In Mice

Acute organophosphorous pesticide poisoning(AOPP)is a global problem that threaten the human health. Recently the World Health Organization(WHO) estimates that there are about three millions people in the world who suffer acute pesticide poisoning per year and most of them are AOPP. Especially in developing countries, not only the incidence rate of the disease is very high, but also the therapy level is poor. In 1995 the death rate of AOPP patients is 12.8 % in China. Pulmonary edema is one of the complications that can often be seen in patients of high-grade poisoning. Some articles reported that the incidence of pulmonary edema in AOPP patients was 20 % to 30 %. The early stage of pulmonary edema is interstitial lung edema. If continued the next period is alveolar edema. Patients of the final stage may die of respiratory restriction of backbone, respiratory and circulatory failure and multiple organ dysfunction. Respiratory muscular paralysis and pulmonary edema can also be the main reasons causing death. So the major target of emergence medicine is to raise success rate of therapy and to reduce case fatality of AOPP. Nevertheless, the pathogenic mechanism of AOPP is not very clear which makes the remedy of it to be a very difficult question. So the purpose of this study is to use dichlorvos(DDVP) to induce pulmonary edema in mice and to explore the pathogenic mechanisms of it. Methods Kunming mice were randomly divided into two groups: Dichlorvos(DDVP)group and saline(control) group. DDVP and saline was injected into peritoneal cavity respectively. Relationship between poisoning dosage and survival time of the animals was detected. Serum cholinesterase...