| Breast cancer is one of the most commonly encountered carcinoma in women. And it is the main cause of death. Insulin-like growth factors (IGFs) play an important role in embryonic and nervous development and tumor formation. IGFs is an important regulator factor in cytopoiesis. It doesn't only control the formal growth, but control the carcinoma. It's an autocrine growth factor in tumor. Insulin-like growth factors (IGFs) is composed of two IGF ligands: IGF-â… and IGF-â…¡,two receptors: IGFR1 and IGFR2, and Insulin-like growth factors binding proteins. These system components from a highly regulated network of interactions both among themselves and between hormones biological signaling pathways. They have been shown to have autocrine, endocrine, and paracrine roles in normal mammary gland biology and in the etiology of malignant transformation. The most important function of IGFs is stimulate mitochysis and differentiation. In the cell of breast cancer, IGFs promote hyperplasia, inhibit death and stimulate transform. Detecting the changes of IGFs in circulation and tissue can directly or indirectly reflect the transfpormation of breast diseases, the microenvironment behavior of endocrine, and can be used as a kind of ideal and potential tumor marker in malignant transformation, development and undergoing treatment for an existing breast tumor. In this experiment we studied the role of IGF-â… and IGF-â…¡in neoplastic multiplication and transfer; explored the relation of IGF-â… and IGF-â…¡with pathological diagnosis, axillary lymph nodes in breast cancer; Gave the experimental and clinical evidence for IGFs as tumor mark to predict and diagnosis breast cancer. 1. Before and after breast surgery in 22 patients with breast cancer, circulating serum concentrations of IGF-â… were measured through ELISA. We contrasted contrast the different expression of IGF-â… with pathologic diagnosis and axillary lymph nodes. The result showed that serum IGF-â… fell in the 7th day after surgery compared with pre-operation. It Manifests that surgery can influence serum IGF-â… .The fibrous tissue besides cancerous node can produce IGF-â… in breast cancer, this result supports IGF-â… has paracrine roles. Carcinoma can produce IGFs to improve growth, this is autocrine. The different IGF-â… has relation with pathologic diagnosis, axillary lymph nodes status in breast cancer. Detecting the change ofIGFs can help diagnose and differentially diagnose breast cancer. IGF-â… has relationship with multiplication and transfer of carcinoma. IGF-â… can improve division , canceration and transfer. Our observations demonstrate that IGF-â… is higher in patients with positive axillary lymph nodes transfer(p<0.05). It Proves that IGF-â… can improve multiplication and transfer of carcinoma. IGF-â… can be used as a kind of tumor marker in malignant forecast and diagnosis. But in Our observations, in different pathologic type of breast cancer the levels of IGF-â… have no difference (all p?0.05). Perhaps the number of patients in our experience is small we can't prove the relation between IGF-â… and malignant phenotype. 2.In breast tissue, high IGF-â…¡can give rise to carcinoma. IGF-â…¡can improve neoplastic infiltration, maintain malignant phenotype. In 22 patients with breast cancer the concentrations of IGF-â…¡in circulating serum before and after breast surgery using radioimmunoassay(RIA) have no obvious difference(p?0.05) ,but in tumor tissue the concentrations of IGF-â…¡is higher than normal tissue. This observation demonstrate that when cell can not control its growth it would be canceration and majority because of the disorder of immune mechanism. The biological property of IGF-â…¡is mediate by specify receptor. |
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