Pro-hepcidin, The Clinic Discussion In The Anemia Of Chronic Renal Failure

Objective To explore the recently detected hepcidin , a central regulator of iron homeostasis,whether plays a role in the pathogenesis of the anemia of chronic renal failure(CRF) and its correlation with EPO and other laboratory markers of iron status or anemia diagnosis in order to give some clues to clinic diagnosis and treatment for the anemia of CRF with turbulence of iron homeostasis by determining its pro-hepcidin concentration.Methods 38 untreated patients with anemia in CRF and 30 normal individuals,6 cases before and after the renal transplant in CRF were studied. ELISA, radioimmunoassay, colorimetric methods etc were used for serum pro-hepcidin(including urinary pro-hepcidin of 11 patients in CRF), EPO, ferritin, serum iron, TIBC and other parameters concentration, respectively.Results serum pro-hepcidin concentration were statisticallysignificntly different between the 2 subsets(P<0.01),and patients group,before renal transplant group were greatly lower than normal control,after renal transplant group. Serum pro-hepcidn showed no statistically significant correlation with EPO,however,it showed inversely changes between them..In CRF,serum pro-hepcidin concentration exhibited a statistically significantpositive correlation with serum ferritin ,MCHC ,Urea ,Crea concentration.negative correlation with CO2CP3CT concentration. Urine pro-hepcidin concentration was significantly higher than serum,but showed no correlation as well with that of serum.Conclusion, hepcidin plays a pathological role in the anemia of CRF.Suppressive regulation of hepcidin by anemia or hypoxia maybe play a primary role in the anemia of CRF so that pro-hepcidin concentration in CRF appears lower than that of normal individuals.But it is possibility that hepcidin concentration is relatively higher than that of non-renal anemia, this will be resolved in future.