A Clinical Investigation Of Diltiazem's Effects On Renal Function In Undergoing Cardiopulmonary Bypass

Objective: To investigate effects of diltiazem on renal function in patients who underwent cardiopulmonary bypass. Methods: Twenty cases of ASA grade â…¡-â…¢undergoing replacement of mitral valve under cardiopulmonary bypass (CPB) were divided into two groups:Treated group (n=10) receiving a continuous intravenous infusion of diltiazem in rate of 2μg╱kɡ╱min from the beginning of CPB and continue for 1.5 hours . Controled group (n= 10)receive no diltiazem.Cr clear ratio(CCR), urine-α₁-microglobulin (u-α₁-MG), urine-β₂-microglobulin(u-β₂-MG) and urine output volume were measured before anesthesia,the duration of CPB,4 hours after CPB and 12 hours after CPB. Results: 1. Before anesthesia there is no remarkable difference between two groups in CCR,u-α₁-MG,u-β₂-MG and urine output volume (p >0.05). 2. In the end of CPB, 4 hours After CPB, the level of CCR obviously decreased in the two groups respectivelyï¹™p <0.05),and it is obviously lower in Controled group than Treated group (p <0.05),but it come back to the base line until 12 hours after CPB in two groups(p>0.05). 3. In the duration of CPB, 4 hours After CPB, 12 hours after CPB the level of u-α1-MG and u-β2-MG obviously increased in the two groups respectively (p <0.05),and it is obviously lower in Treated group than Controled group (p <0.05). 4. In the duration of CPB, 4 hours After CPB, 12 hours after CPB the level of urine output volume obviously increased in the two groups respectively (p <0.05),and urine output volume is lower in Controled group than Treated group (p <0.05). Conclusion: 1. Cardiopulmonary bypass have a negative effection on renal function. 2. Diltiazem has protection on renal function in patients who undergoing Cardiopulmonary bypass.