| Objective: To analyse the independent clinical factors that affected the survival of patients with soft tissue sarcomas under 18 year-old and discuss the management strategies of these soft tissue sarcomas and review relative literatures. Patients and Method: There were 120 patients with soft tissue sarcoma between Jan 1989 to Dec 2002. All 53 cases with rhabdomyosarcoma (RMS), we inducted nine clinical factors include age, sex, primary site, histological type, tumor size, pretreatment stage, IRS group, wide margin resection, selection of chemotherapy regiment, and analysed in statistic methods. All 67 cases with nonrhabdomyosarcomatous soft tissue sarcoma (NRSTS), six factors were inducted include age, sex, tumor size, IRS group, with/without chemotherapy and with/without radiotherapy. Then the statistical analysises were performed. Result: The independent clinical factors such as tumor size, wide margin resection, IRS group and selection of chemotherapy regimen could affected survival of patients with rhabdomyosarcoma in children and adolescent. The 2-year evant-free survival of different tumor size were 57.14% versus 12.00%,; wide margin resection in final and unable resection in wide margin were 59.26% versus 11.54%; EFS of group I to IV were 90.00%, 54.55%, 14.29% and 0.00%,respectively. In NRSTS, the IRSgroup was the unique clinical factor that affected survival. Survival of patients with resected entire tumors was better than the patients with residual tumors. The EFS of group I to IV were 93.55%, 75.00%, 20.00%, and 0.00% , respectively. Conclusion: Multi-modality management is optimal for the patients with RMS in children and adolescent. The aim of treatment is no residual tumor tissues after initial resect, the unresectable tumors and residual tumors could achieve wide margine excision through neoadjuvant therapy and/or adjuvant chemotherapy. The regulated and appropriate... |
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