| Objective Temporal lobe epilepsy is a complicated clinical syndrome, only depend on medication can not to efficient control the symptom, so seizure foci removal is requisite, and orientated seizure foci is regard as the first precondition to established project of operation. Multivoxel MR spectroscopy offers an additional noninvasive method of supporting focus lateralization in patients with temporal lobe epilepsy. The objective of our study is evaluate the value of multivoxel magnetic resonance spectroscopy in the orientation of temporal lobe epilepsy.Methods A total of 30 patients with specific symptom manifestations and temporal lobe epilepsy confirmed by niveau diagnosis were enrolled in this study, some symptomatic temporal lobe epilepsy patients with intracerebral tumor or vascular malformation diagnosed by MRI were excluded from study. All patients were performed EEG , routine MRI and multivoxel magnetic resonance spectroscopy at bilateral hippocampal areas. Amalgamated the colour-coded imaging which relative signal intensity of metabolites and oblique coronal high T2 weighted imaging, to measured N-acetylaspartate acid (NAA) and choline-containing compounds(Cho) signal intensity in bilateral hippocampal areas. The distributing of metabolites in bilateral hippocampal areas would be analysed straight.Results The signal intensity of NAA in the epileptic lateral (6804.14 + 2473.53) Mr units were significantly decreased compared with the contralateral signal intensity (8413.64 + 2784.59) Mr units, (t=-4.97, P<0.001) . The ratio of Cho/NAA in the epileptic lateral (1.43 + 0.17) were significantly increased compared with the contralateral ratio (1.18 ± 0.19), ( t=6.49, P<0.001). Through the amalgamation of the colour-coded imaging and the routine MRI imaging, the... |
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