A Research About Distribution And Antibiotic Resistance Of Bacteria In Respiratory Department Of Our Hospital During The Period Of 2003～2004

Nowadays, with the ceaseless appearance of antibiotic drugs, the morbidity and mortality of infective diseases are still at a high level. Because of the extensive applications or not fitting usages of antibiotics, the categories, pathogenicity and sensitivity to antibiotics of pathogen have changed greatly. The emergence of the antibiotic resistance and the infection of the resistant bacteria usually results in the defeat of experiential diagnoses and therapies, which brings a tremendous challenge to the therapy of anti-infection in clinic. In order to assess the status of familiar pathogen and resistance to antibiotics in clinic presently, offer referential suggestion for doctors to choose antibiotic drugs suitably, treat the infective diseases effectively and control the spread of the resistance, 710 cases of respiratory infective diseases were analysed retrospectively in respiratory department of our hospital during the period of 2003-2004. The results show that there were only 329 specimens of sputum which had been cultivated in the 710 cases. The ratio of sputum cultivated was 46.3%. 164 pathogens were found altogether. 53 of them were fungi (16.1%), 111 of them were normal bacteria (33.7%).Among them, 16 cases were Escherichia coli (14.4%); 12 cases were of Streptococcus aureus (10.8%); 9 cases were Streptococcus pyogenes (8.1%); 9 cases were Klebsiella pneumoniae (8.1%); 9 cases were MRSE (8.1%); 8 cases were Staphylococcus aureus (7.2%); 6 cases were Pseudomonas aeruginosa (5.4%). Most bacteria were resistant to ampicillin, the firs and second generational cephalosporins, aztreonam, macrolide, nitryl furan and sulfapyridine (>70%). The resistant ratio to aminoglycosides and the third generational cephalosporins were very high too (>50%). The resistant ratio to quinolones were lower relatively (<50%). The sensitivity to the fourth generational cephalosporins, the complex of β-lactamase, imipenem and glycopeptide were still at a high level. The research indicate the following conclusions: The ratio of sputum cultivated and the ratio of bacteria separated are still very low in clinic presently, so the doctors should make the best use of the microorganism laboratory to take the specimen to cultivate the pathogen and take the antimicrobial sensitivity test as early as possible, and the construction of the microorganism laboratory should be strengthened; The fundus inefection is very serious presently, and the doctors should use antibiotic drugs suitably to reduce the occurrence of fundus infection; Most pathogen of infective disease are opportunistic bacteria, so doctors should pain more attention to patients'bacterial status and adjust the patients'immunity actively with treating the infective disease; The ratio of bacterial resistance to antibiotic drugs is very high, especially for the resistant bacteria caused by producing β-lactamase, so doctors should use antibiotic drugs suitably, make antimicrobial sensitivity test actively and use antibiotic drugs according to the result of the AST. However, because of being affected by many factors, the experienced usage of antibiotic drugs is still the main method of antibiotic therapy. What's more, the experienced therapy cann't be replaced by the objective therapy in a period of time. Before acquiring...