| Objective Bold oxygenation level dependent functional magnetic resonanceimaging (BOLD-fMRI) was used to observe the activated volumes of motor andvisual cortex diseases pre-and post-therapy and to compare with normal subjects tovalue BOLD-fMRI quantitative analysis on rehabilitation therapy. Materials andMethods 58 subjects including 21 patients and 37 normal volunteers took fMRI invisual and motor cortex,17 normal volunteers and 6 patients whose visual cortex weresuffered from tumor or infarction or any other lesions in left cerebral hemisphereundertook fMRI examination and were followed up in 3 months after therapy .20normal volunteers and 15 patients whose motor cortex were lesioned undertook fMRIof motor cortex, and six of them followed up in 1～14 days,1 month ,3 months aftertherapy. EPI sequence was used to compare with two kinds of block design fMRI(ONand OFF) in both visual and motor cortexes and to observe how the two cortex'sactivated volumes changed under various stimulation modes. Results 1,motorcortex :there was significant differences in motor cortex activated volumes between20 normal volunteers in right hand and both hands finger to finger running mode(p<0.05),while there were no differences between right hand and left hand ,left handand both hands motor mode(p>0.05).there were great differences among motor cortexlesion patients pre-and post-therapy. 6 of these patients took therapy in 1-14 days,1month and 3months after therapy respectively and dramatic differences can be seenamong their relevant active cortex volumes. Further more, we can find that thevolumes increased sharply in the first 1-14 days but slowly increased after 1 and 3months therapy. The volumes of active cortex after 1-14 days and 3 months of therapyare different but similar after 1 and 3 months'therapy. A general regulation is thatpatients'activated volumes is smaller than normal volunteers', but they will becomelarger gradually after therapy.7 patients'activated volumes was dramatic differentbetween left hand and both hands fingers running mode, while there was no differencebetween right and left hand ,right and both hands(p>0.05) mode.2,Visual cortex: There were no dramatic difference of activated volumes in 17normal volunteers'visual cortex between synchronic stimulation and unsynchronizedstimulation in the ways of both eyes, right eye and left eye, and single lateralstimulation and bilateral unsynchronized stimulation. No light stimulation is ratherdifferent with any other four modes(p<0.05).We can find that the activated volumes ofboth-eyes'stimulation were larger than that of single-eye stimulation. It was retained afixed value 105 mm3 on the way of no light stimulation, but just only few activatedvolumes is far larger than 105 mm3. The pre-therapy activated volumes of 6 patients'visual cortex is smaller than that of post-therapy activated volumes, but both of themare smaller than that of the normal group activated volumes. Conclusion 1,Theactivated volumes of cerebrum can be quantified exactly by AFNI. We can view theirdistribution characteristic, and value the patients'rehabilitation. 2,The activatedvolumes of visual and motor cortex vary with the changes of pathogenetic condition,the general trend is that the volumes of disease is smaller than that of the normal, andthe volumes of post-therapy in the beginning 1-14 days is significantly larger than thatof pre-therapy. As time going, the activated volumes of relevant cortex will becomelarger than before though their increasing extent is lower than that of the former. Sowe propose that 7-14 days after therapy undergoing bilateral motor training is the bestrehabilitation time for motor cortex lesion patients to improve nervous system. 3,Thevolumes evoked by bilateral stimulation is larger than that of the unilateral. 4,Theactivated volumes constantly holding 105 mm3 at the situation of no light stimulationmaybe result from the systematic noises ,but the distinct activated volumes exceeding105 mm3 maybe evoked by imagination. |
PDF Full Text Request