Quantitative Evaluation Of Regional Wall Motion During Myocardial Ischemia And Reperfusion By Quantitive Tissue Velocity Imaging

objective To discuss the feasibility of quantitive tissue velocity imaging (QTVI) to quantify regional myocardial dysfunction induced by acute ischemia and reperfusion. The results derived from this study provide experimental foundation for QTVI in estimating the segment of myocardial ischemia and evaluating viable myocaridium after reperfusion. Methods Note the peak velocity of the systolic wave (Vs)and the peak velocity of the early diastolic wave (Ve) of regional Wall segments of Seven dogs with left anterior descending coronary artery(LAD) ligated under the different examination time points(i.e.,pre-ligation,basic state;post-ligation 5min ,15min ,30min,60min,120min and reperfusion) by using QTVI technique. Postoperation the myocaridial specimen stained by 1% triphenylatetrazolium chlorde(TTC) solution and tissue structure were analyzed by transmissible electrical microscope to identify whether myocardium was necrosis or not. Then note NO and NOS of different examination time points to discover the pertinence between QTVI and NO and NOS. Results Vs,Ve of every segmental myocardium of the dogs which under ligation 5min ,10min fall evidently ,compared with the dogs under the basic stateP<0 05.After the ligation Vs begin to come back 30min later,while Ve come back slower ;Vs and Ve also have a quick tendence of recovery after reperfusion.,but lower than the basic state. There is evidence change of LAD affusing area ahead wall of left ventricle and anterior especially apical segment of these ,P<0.05. Then the change in inferior septal and lateral wall is not obvious ,with the Vs and Ve of inferior wall and post wall raise .And there is no pertinence between QTVI and NO and NOS throngh statistical analysis. Conclusions QTVI could quantify regional wall motion abnormalities( Regional myocardial dysfunction) during myocardial ischemia and reperfusion. And QTVI is useful for clinical diagnose and trestment of decision-making on acute myocardial ischemia.