Expression Of Lipid Metabolism-related Genes ADRP And LPL And Its Role In Placental Tissues From PIH Patients

Pregnancy-induced hypertension (PIH) is one of the main causes of perinatal morbidity and mortality. However, its particular pathogenesis has been remained unknown after intensive studies for more than a century. At the present, the study of pathogenesis in PIH is focus on: dysfunction of placenta, endothelium dysfunction, disorder of lipid metabolism, heredity and inflammatory reaction. The disorder of lipid metabolism play an important role in PIH pathogenesis. Lipid metabolism-relate genes: adipose differentiation-related protein (ADRP) gene and lipoprotein lipase (LPL) gene are crucial genes in the lipid metabolize. Using cDNA microarray, Li Donghong et al found 22 differentially expressed genes in PIH patients placentas, including ADRP (NM₀01122) and LPL (NM₀00237). Therefore, investigatation of the expression of ADRP and LPL in PIH patients' placentas may provide more information to benefit elucidating PIH pathogenesis. ObjectivesTo investigate the expression of lipid metabolism-related genes, ADRP and LPL in placentas of PIH at the mRNA and protein level respectively and...