The Effects Of Sufentanil And Remifentanil On The Recovery After Laparoscopic Cholecystectomy In Elderly Patients

BackgroundBoth a single dose of Sufentanil, a longer-acting opioid, or the continuous infusion of Remifentanil, a short-acting opioid, as part of an intravenous or a combined intravenous-inhalation anaesthesia protocol provide effective and safe analgesic treatment in young patients undergoing selective laparoscopic cholecystectomy (LC). Factors complicating use of opioid in the elderlys are the physiological changes of ageing with a reduced organ reserve and the presence of comorbidities. Deterioration in renal or hepatic function may force the doses of opioid to be adjusted. The safety and effectiveness of Sufentanil for the analgesic treatment is unclear. This study was to investigate the effects of equivalent doses of Sufentanil and Remifentanil on postoperative pain,nausea, vomiting and the patients' postoperative recovery in elderly patients undergoing selective LC.ObjectiveTo study Sufentanil, a longer-acting opioid and Remifentanil, a short-acting opioid, with regard to their ability to reduce the postoperative effects and facilitate laparoscopic cholecystectomy in the elderly patients surgery.MethodsSixty elderly patients scheduled for elective laparoscopic cholecystectomy were randomized into two groups. Sufentanil was used in group S as part of the anesthetic protocol, while Remifentanil was used in group R. Degree of pain and nausea, frequency of vomiting and analgesic medication consumption were recorded. Time between surgery and to the start of micturition, drinking, mobilization, dressing, and discharge was recorded. Patients registered their satisfaction on a VRS.ResultsThe patients in the R group had a significantly higher degree of pain at 10 min, 20 min, 30 min and 1 hour post-op, comparing with those in S group (p < 0.05). While, there was no significant difference inpostoperative pain after 1 hour post-op between two groups, and no significant difference in nausea, vomiting, recovery and satisfaction between two groups (all p > 0.05).ConclusionBoth anaesthetic protocols can therefore be safely and effectively used in elderly patients undergoing selective laparoscopic surgery. Sufentanil may provide superior pain relief over the first hour post-op, comparing with Remifentanil.