Value Of Early Diagnosis About Urine Epidermal Growth Factor Level In Children With Henoch-Schonlein Purpur Nephritis

Objective: To investigate the value of early diagnosis about urine epidermal growth factor( EGF) concentration change in children with Henoch-Schonlein Purpura nephritis (HSPN).Methods: Adopted Bi-antibody ELISA to detect the urine EGF and RBP levels in 91 HSP and 30 healthy children. The urine MA level was detected by automatic special protein analyzer.Results: (l)The urine EGF concentration in HSP patients ( 78.59 ± 18.09ng/ml) was significantly higher than that of control group ( 29.30 ± 13.92ng/ml ), the difference was remarkable (t=13.64, P<0.01). Comparison in every kinds found that the urine EGF concentration ( 89.31 ± 17.68ng/ml) in purpura nephropathy was higher than that in any other kind: skin type ( 78.76 ± 12.66ng/ml ), abdominal type ( 77.16 ± 11.77ng/ml), joint type ( 76.49 ± 17.45ng/ml), mixed type (77.71 ± 13.49ng/ml), there were clinical statistical significance ( both P<0.05 ), but there were no statistical significance in the latter four kinds ( both P > 0.05 ) .(2) The comparison of urine EGF in acute period ( 78.89 ± 18.11ng/ml) and convalescence period( 81.76 ± 12.25ng/ml) of 30 HSP showed that there was no statistical significance (t' =0.72, p > 0.05 ) .(3) The concentration of urine MA in HSP group was (43.21 ± 10.23mg /l) , much higher than that in control group ( 6.41 ±2.86mg/l), there was...