A Relative Analysis Of Coronary Artery Lesion And Plasma Lipid

Objective: To study the relationship of the severity between the levels of plasma lipids and coronary artery disease (CAD). Methods: The levels of plasma lipids including of total Cholesterol (TC), Triglyceride (TG), High-density lipoprotein cholesterol(HDL-C), Low-density lipoprotein cholesterol(LDL-C), apolipoprotein A (apoA), apolipoproteinB(apoB) and Lipoprotein(a)[Lp(a)] of 184 patients with coronary artery disease (CAD)and 90 normal persons were measured. According to angiography, patients with coronary artery disease (CAD) were divided into single-,double-,and triple vessel groups. Results: The levels of plasma TC, TG, LDL-C, apoB and Lp(a) were obviously increased and apoA, HDL-C reduced in CAD than in control; The levels of plasma apoA. ApoB and Lp(a) were obviously increased and the level of plasma apoA was obviously discreased with the severity disease group than slight and middle disease groups (P<0.05). Level correlative analysis shows that as the stenosis vessels increased, the stenosis mark also increased, according the levels of apoB and Lp(a) yet increased ,but the level of apoA discreased. Conclusions: The levels of plasma apoA,apoB,Lp(a) correlate with the coronary disease. Lp(a) is an independent risk factor of coronary artery disease (CAD) .The levels of apoA and apoB and Lp(a) correlate with the severity of coronary artery disease. There is an important reference value and clinical significance for predicting coronary artery disease and its severity.