The Experimental And Clinical Studies On Free Autogenous Iliac Bone Graft

Bone graft continues to be the standard for the reconstruction of the facial bone defects caused by tumor and trauma, and the atrophy alveolar caused by teeth missing. Autologous bone remains to be the golden choice of the bone graft materials. While, how to accelerate the graft bone healing process and reduce the pathologic resorption, is what we desire to make clear now.Vascular endothelial growth factor (VEGF) is the most critical growth factor for angiogenesis, and matrix metalloproteinase-9 (MMP-9) is associated with extracellular matrix degrading and bone resorbing. In this study their expressions are studied to investigate the mechanisms during the angiogenesis and regeneration process of grafted bone.PART I: Free autogenous iliac bone graft models were performed in rabbits. The healing process was studied using standard histomorphometric method. VEGF and MMP-9 were determined by means of immunohistochemistry (two steps method), and their effects during the healing process, and their expression patterns were investigated. A time and region dependent expressions of bone remodeling were observed. These results suggested that VEGF and MMP-9 were involved in bone graft healing process.PART II: Twenty-eight mandiblular reconstructions were performed for oncologic defects, and their cases were studied. This paper reviews the indications and limitations, to provide experiences for-clinical work.