1829 Patients With Primary Colorectal Cancer: Clinicopathologic Features And Prognosis

Objective To evaluate the relationship between clinicopathologic features and prognosis of colorectal cancer. Methods This retrospective study of patients with histologically proven adenocarcinoma is to evaluate the prognostic factors in colorectal cancer by univariate and multivariate analyses of Cox regression with SPSS 10.0 software. 1829 patients with primary colorectal cancer operated in Tian jin Cancer Hospital were studied and follow up until Jan, 2004 or death. Results (1) The mean survival time of 1829 colorectal cancer patients was 76.79 months and the overall 5-year survival rates were 56.89%. The mean survival time of 787 colon cancer patients was 79.78 months and the overall 5-year survival rates were 59.70%. The mean survival time of 1042 rectal cancer patients was 74.14 months and the overall 5-year survival rates were 54.19%. (2) Univariate analysis showed that the predictors of survival in colorectal cancer patients were age, symptom time, tumor location, radical resection, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, distant metastases and Dukes' staging. Multivariate analysis showed that only tumor location, radical resection, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, and Dukes' staging were independent factors. (3) Univariate analysis showed that the predictors of survival in colon cancer patients were tumor location, radical resection, perioperative blood transfusion, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, distant metastases and Dukes' staging. Multivariate analysis showed that only radical resection, depth of tumor invasion, lymphatic invasion, and Dukes' staging were independent factors. (4) Univariate analysis showed that the predictors of survival in rectal cancer patients were sex, diagnosis age, symptom time, radical resection, histological type, diameter of the tumors, depth of tumor invasion, lymphaticinvasion, distant metastases and Dukes' staging. Multivariate analysis showed that only sex, radical resection, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, and Dukes' staging were independent factors. (5) There were .difference between right side colon cancer and left side colon cancer in histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, and Dukes' staging, the prognosis of right side colon cancer was poorer than left side colon cancer. (6) There were difference between colon cancer patients and rectal cancer patients in age, symptom time, radical resection, perioperative blood transfusion, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, and Dukes' staging. But there was no difference in the survival times between them. (7) There were difference between young patients and old patients with colorectal cancer in symptom time, tumor location, histological type, lymphatic invasion, and Dukes' staging. But there was no difference in the survival times between them. Conclusion (1) The following prognostic factors can influence the survival of colorectal cancer patients: tumor location, radical resection, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, and Dukes' staging. (2) The following prognostic factors can influence the survival of colon cancer patients: radical resection, depth of tumor invasion, lymphatic invasion, and Dukes' staging. (3) The following prognostic factors can influence the survival of rectal cancer patients: sex, radical resection, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, and Dukes' staging. (4) There was difference in the clinicopathologic features between colon cancer patients and rectal cancer patients. (5) The clinicopathologic features of young patients and old patients with colorectal cancer were different.