Expressions Of EMMPRIN And Matrix Metalloproteinase-2 In Laryngeal Carcinoma And The Relationship With The Invasion And Metastasis

Objective Laryngeal carcinoma is the common malignant tumor in head and neck, and the tumor cell invasion of laryngeal carcinoma is responsible for both local destruction and metastasis. Invasion is largely mediated by matrix metalloproteinases that is thought to be induced by extracellular matrix metalloproteinase inducer (EMMPRIN) in surrounding fibroblasts. The aim of this research is to investigate the expressions of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-2 in human laryngeal carcinoma, and to learn the relationship between the expressions and with the clinicopathological features. Methods The expressions of EMMPRIN and MMP-2 were detected by the method of immunohistochemical S-P in 47 specimens of laryngeal carcinoma and 22 specimens of normal laryngeal tissues. The relationship between the expressions and with the clinicopathological features was analysed. Results Positive expression rates of EMMPRIN and MMP-2 in laryngeal carcinoma were 87.2% and 91.5% respectively, higher than 9.1% and 18.2% in normal laryngeal tissues. In laryngeal carcinoma, the intensive expression rates of EMMPRIN and MMP-2 had a positiverelationship with histopathological grade, clinical phase and the situation of cervical lymph node matastasis. The co-expression rate of EMMPRIN and MMP-2 was 85.1%. Significant correlation was found between the expression of EMMPRIN and that of MMP-2 in laryngeal carcinoma. Conclusion As the major enzyme to degrade native collagen type IV, a main component of extracellular matrix and basement membrane, MMP-2 and its inducer, EMMPRIN express in laryngeal carcinoma. The expressions of EMMPRIN and MMP-2 have relevance to histopathological grade, clinical stage and cervical lymph node matastasis of laryngeal carcinoma. Increased expression of MMP-2 might be induced by EMMPRIN expressed in laryngeal tumor cells. The expression of MMP-2 and EMMPRIN may be a biological mark to diagnose and learn the invasive ability of laryngeal carcinoma.