A Study On The Influences Of Human Physiological And Biochemical Index In Hyperthermia And High Humidity Environment

BackgroundIt is well known that hyperthermia can effect on the metabolism and inner environment of human body. Especially, it may injury brain cell and increase significantly the mortality of the patients who undergo craniocerebral trauma or cerebral hemorrhage. Hypothermia therapy was applied on medical treatment several centuries ago and was tried in cerebral diseases in the early of 19th .There were not a satisfying results due to the shortcoming of physical cooling and there were frequently severe complications, such as shivering , arrhythmia, coagulation disorders and increased risk of pulmonary infection and so on . As a result , the application of hypothermia was limited in medical treatment.Until the present, there is not report about drug cutting down the temperature of human body in all over the world except there was a report of using SunN4507(5-HT1A acceptor selectivity appetency) as experimental treatment on cerebral paralysis in Japan. SunN4507 is applied during the acute stage and it is too expensive to suit of use in common practice. So this study start out from the practical application and use urapidil(that isfamiliar with SunN4507 in pharmaco-character but it is cheaper than SunN4507) as one interfere factor. So we develop this experimental study to approach the influences of motion on human physiological and biochemical index in hyperthermia and high humidity environment and the mechanism of drug(urapidil) to cut down the brain temperature. It aims at providing the basis for the drill of soldiers and medical treatment on clinical patients in the future . ObjectiveTo investigate the influences of motion on physiological and biochemical index of human body under hyperthermia and high humidity environment and to provide the basis for the drill of soldiers and medical treatments on those patients who are complicated by hyperpyrexia or stayed under the hyperthermia and high humidity environment after cerebral trauma and cerebral hemorrhage. Methods90 soldiers are randomly shared in three groups, such as older soldiers group (enrollment over 2 years, age 22~28a, average 24.37a), younger soldiers group (enrollment beyond 2 years, age 16~22a, average 19. 86a), and younger soldiers dose group (given a dose of 30 mg urapidil partly before 7 and 3 hours of motion, enrollment beyond 2 years, age 16~22a, average 19.23a). They are arranged to run for 3000m within 20 minutes under the hyperthermia and high humidity environment (tiptop temperature up to 60&, relative humidity up to 80%). Their physiological and biochemical index are observed before and after the motion instantly. ResultsThere are no significant difference in temperature, blood pressure, pulse, electroencephalography and biochemical indexamong the three groups before the exercise but significant difference in temperature, pulse , hemorheology , Na+ , Cl~ and Bun after the motion among the three groups. There are also not significant difference in blood pressure, K +and Glu among the three groups even after the motion . ConclusionHyperthermia and high humidity have district effects on temperature, pulse , hemorheology , Na+ , Cl~ and Bun of human body. There are significant difference among the three groups because old soldiers lived longer and are more adaptive under the hyperthermia and high humidity than new soldiers do. The index of younger soldiers change most significantly , the index of older soldiers change secondly, and the index of the dose group soldiers change leastly. Meanwhile the urapidl can degrade the metabolism and cut down the fluctuation of the physiological and biochemical index of human body. Their electroencephalography don' t change significantly and they all have normal electroencephalography before and after motion.