| ObjectivesrWe hypothesize that stagnation of qi and blood and damage of heart collaterals are important causal mechanism of UA, and the way of regulating qi ,promoting blood circulation and removing obsruction in the collaterals are effective treatment principle through extensive empirical studies of clinical symptom and pathology of UA patients. Based on that, we developed a concrete treatment approach shuluodingtongyin, aiming to study the efficacy and mechanism of this approach.Methods:We randomly assigned 62 UA patients into treatment (32) and control (30) groups, and we studied two groups in terms of their clinical symptom, change of electrocardiogram, blood lipid, blood pressure, and function of heart respectively. Based on the successful building acute myocardial model in 60 cases of rats, we were able to compare differences between treatment and control groups in terms of change of electrocardiogram,TXB2,ET,SOD,NO,CD62p,CD63.Results:We found that shuluoding tongyin, which has the efficacy of regulating qi .promoting blood circulation and removing obsruction in the collaterals, obviously alleviate patients' clinical symptom, change of electrocardiogram, myocardial, function of heart and so on; Experiments on R.norvegious showed that the treatment can significantly change acute myocardial. Both clinical trials and animal experiments showed that regulating qi .promoting blood circulation and removing obsruction in the collaterals could decrease the level of TXB2- ET, CD62p, CD63 and increase the level of NO, and concentration of SOD in the blood.Conclusion:Our findings from both clinical trials and animal experiments showedthat regulating qi ,promoting blood circulation and removing obsruction in the collaterals is functioning from several different perspectives, such as mitigating acute myocardial and convulsion of coronary artery ,improving function of vessel and so on . anti-Our hypothesized treatment is proved to be an important way of treatment. |
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