The Study On The Relation Between Intractable Epilepsy In Child And Multi-drug Resistance Gene Associated P-glycoprotein

Objective: Epilepsy(EP) is a common disease in nervous system, which collective prognosis is preferable, but sill a part of its can't cure with therapeutic Method at present,which is intractable epilepsy. the pathogenesis of IP becomes the study keystone, and the heighten of MDR's expression causes medical attention. the objection is studying the relation between the epilepsy in children and multi-drug resistance gene and discussing the likely pathogenesis. Method: To detect the expressive levels of perihemo-lymphcell membrance glyco-protein in 25 children with of epilepsy and 8 healthy children by flow cytometer analytic method. All the studied objects'conditions are coincidence with the diagnosis standards about epilepsy and intractable epilepsy at present, eliminating the other out-breaking diseases. According to the clinical situation.,electroencephalogram results and clinical therapy results, these studied objects are divided into intractable epilepsy group,partial seizure group,total seizure group；the control group is 8 healthy children without difference on age and sex. Results: (1) the expressive levels of perihemo-lymphcell membrance glyco-protein in all 25 children with epilepsy were higher compared to the control group(1.4980±0.48),and the levels of perihemo-lymphcell membrance glyco-protein in children with intractable epilepsy(36.1713±5.67%) were highest ,detected by SLD-t,(P<0.001)there was statistic significance.(2) The expressive levels of perihemo-lymphcell membrance glyco-protein in 8 children with intractable epilepsy were higher compared to the other children with tractable epilepsy(21.2113±4.32%,16.4743±2.04%) ,detected by SLD-t(P<0.05),there was statistic difference.(3)There were no statistic difference between the two group children with common epilepsy, detected by SLD-t(P>0.05), there was no statistic significance .Conclusion: the heighten expressive level of P170 is likely one of the pathogenesis of intractable epilepsy;P170 may act the diagnostic marker of intractable epilepsy; the expressive levels' heighten of perihemo-lymphcell membrance in children with epilepsy may caused by diseases itself and ADES itself, So early ,reasonably, actively control the attack of epilepsy may less the formation of intractable epilepsy; The level of P170 may be helpful to detect the formation of drug-resistance early. Thus the level of P170 in blood has an important clinical significance.