| Chronic glmerulonephritis (CGN )is a set of disease derived from glomerulus. It is caused by several reasons and consisted of many pathologies . The youngers and children's incidence rate is higher than others. CGN's clinical character is long term abnormal urina, for example: proteinuria and(or) hematuria, chronic progressing renal function damage, hypertension and(or) oedema, finally it will become contracted kindney and entire and final phase kidney porstration. Because CGN's progress is long,the cause of disease is uncertain, there is no definite relationship between CGN and acute glmerulonephritis(only 10 percent or so have streptococcal infection and acute glmerulonephritis history),most of chronic glmerulonephritis are developed from other primary renal glomerular diseases, these reasons caused the progress chronicity and nephron is destroyed continuously.The falling ill principles of CGN which is known now are the following: â‘ The immune inflammation of the original disease is active. â‘¡renal substantial hypertension causes renal arteriolosclerosis. â‘¢ Glomerulosclerosis which is mediated by glomerular henmdynamics leads to the proliferative and sclerosing of glomerulus and membranous nephropathy. With the developing of the progress, the renal glomerular disease pathology alters its character and disappears gradually. And becomes aniso-degree glomerulosclerosis sacculus ischemia change and sclerosis of small blood vessels. The corresponding nephron dries up and shrinks. The renal interstitium becomes focal and fibrosis. Chinese medicine hold the view that CGN's progress is long and the fall ill principle is complicated, zhengqi weak and xieqi strong is its main foundation of the fall ill principle. In ancient time there is the theory of "long time disease will enter luo", "long time disease lead to blood clot".The change of fall ill principle is the damage of the three visceras: the lung, the spleen and the kidney, the disproportion of negative and positive qi xue the disproportion, shui ye stayed inside, qi xue gastric stasis and become blood clot, moist leads to clot ,moist and clot congeal with each other. The modern pathology research of CGN mainly focus on the reduction of blood flow ,degeneration etc. It is a kind of allergic reactive disease. This is concide with Chinese medicine theory of "blood clot" and "xue xing bu chang".During the clinical, there are some ordinary anticoagulant medicines such as hepcine and warfarin because of their lower side effect and easily surveillance. If blood vessels have been clot by coagulatant, we always select UK.SK, but some of them have side effect for example: blooding, Sk also lead allergic reaction. So active principle extract of Chinese herbs become the hot topic to treat blood viscosity of CGN. Now the injections of Saliva Miltiorrluza, Puerarin and fleabane are ordinary therapeatic medicine. Ginkgo Biloba, a natural extract, is the effective conposition of Chinese herbs.In clinical it mainly used in cardio-cerebral, and it can improve the patientes' blood rheological index. But we only research few reports about the using of EGB in CGN, especially in mainland. This study is to observe the effect of how EGB treating the CGN' s hyperviscosity and change of renal function and lipid metabolism. The study also will discuss the theory of EGB treating CGN's blood viscosity.This experiment includes clinical observation and experimental research. In clinical observation, there are 54 patients, including 32 men and 22 women, with the age averaging 41(18-59 years old). Who are selected from the Traditional Chinese Medical Department of Sino-Japanese Friendship Hospital of Ji Lin University Kidney Department. The patients are divided by two groups (therapeutic group and control group) according the random principle. All patients conform to the Diagnose Standard of the group of the renal disease of CGN in July, 1992. Two groups received the conservative treatment. The therapeutic group was given Tabel of Ginkgo Biloba 38.4mg,... |
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