ã€Objective】 To study the feasibility of bispectral index(BIS) and auditory evoked potential index(AEPI) modulating the depth of anesthesia in the elderly patients during the target controlled-infusion(TCI) of propofol general anesthesia.ã€Methods】Forty five ASA physical status of â… -â…¡ patients with normal hearing undergoings selective surgery were divided into three groups with 15 cases each:The patients in the elderly groups (group â… and groupâ…¢ ) were 65-80years old, in the younger 20-65 years old (group â…¡). The anesthesia was induced by fentanyl,propofol,suxamethonium and maintained with TCI in all patients. The target concentration o f propofol was modulated by AEPI and BIS in groupâ… and â…¡ ,and by hemodynamics in group â…¢.the changes of HR ,SBP, DBP, MAP, AEPI and BIS were recorded at the eight times during anesthesia. Total dose of propofol, duration of the anaesthesia , the emergence time after discontinuation, the perioperative awareness were recorded,too. ã€Results】 In all patients, SBP, DBP and MAP significantly decreased at intubation(p<0.05). At 5min after intubation,the hemodynamics was significantly lower than the baseline in group â… (p<0.05), but was higher than after intubation . The hemodynamics at discontinuation was significantly higher than at exploration (p<0.05) in group â… ; While the changes was not significantly different in group â…¡. In group â…¢, the hemodynamics at incision skin was significantly higher than after intubation (p<0.05) .The hemodynamics at discontinuation was significantly higher than at exploration (p<0.05) in group â…¢.BIS and AEPI were not significantly different in three group. There were significant correlation between BIS and AEPI (r=0.780,0.781,0.752) (p<0.01). The standardized unit dose of propofol was 106.43μg?kg-1?Min-1 in group â… , 123.11μg?kg-1?Min-1 in group â…¡, 116.76μg?kg-1?Min-1 in group â…¢. The standardized unit dose of groupâ… was significantly lower than that of groupâ…¡ and group â…¢(P<0.05).There wasn't awareness in groupâ… and group â…¡, There were two awarenesses in group â…¢. Time of emergence in the group â…¢ was significantly longer than that of group â…¡ and group â…¢(P<0.01). ã€Conclussion】 Anesthesia with target controlled-infusion propofol modulated by AEPI and BIS in the elderly is feasible with the advantages of keeping stable hemodynamics, avoiding prolonged emergence.There were consistent between AEPI and BIS.
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