Research Of Correlation Between CCK,CCK-A Acceptor, VIP And Gallstone

Objective:Cholelithiasis is a worldwide disease. It has connection with area,fatness,age and useness of estrogen.In these years,the threaten of cholelithiasis to health of human is becoming bigger and bigger.Among these,the gallbladder cholesterol stone is in major station.This experiment discuss the possible mechanism of cholelithiasis through the gallstone group,gallbladder polypi group and control group's studies of gallbladder B-ultrasound,CCK,CCK-R and VIP.It offer some theory gist and clinic experiment data for finding the action of exceptional gallbladder function to gallstone and so that we can prevent it's happening. Methods:Gallbladder function was measured with B-ultrasound of gallstone group: 36(male 16 and female 20), 50.06 years olds on average,gallbladder polypi group:30(male 12 and female 18),47 years olds on average and control group:30(male 15 and female 15),50 years olds on average.All the three groups have not hypertension,diabetes and other endocrinopathys. Determine preprandial and postprandial gallbladder's cubage. Use natural gallbladder contraction rate E decrease 1.96s (E-1.96s=46﹪).Divide gallstone group into natural group(A1,20,E>46﹪) and depressed group (A2,16 E<46﹪)with the standard 46﹪.Determine serum level of CCK and VIP. Determine the numbers of CCK-R which exists in gallbladder wall.Results:1.Postprandial CCK and VIP of depressed group , natural group,Gallbladder polypi group and control group increased significantly than preprandial CCK and VIP (P<0.01 or P<0.05).2.Compared with other three groups, hollow gallbladde cubage of natural group increased significantly (P<0.01).3.Compared with other three groups, gallbladder contractility rate of depressed group decreased significantly (P<0.01).4.Compared with other three groups,preprandial CCK of natural group increased significantly(P<0.01).5.Compared with depressed group, postprandial CCK of natural group increased significantly(P<0.05).6.Compared with other three groups,postprandial VIP's increasing degree of depressed group increased significantly(P<0.01).7.Compared with gallbladder polypi group, CCK-R of gallstone group decreased significantly. Conclution:1.B-ultrasound is a comparatively perfect method which is used to observe gallbladder cubage,evaluate gallbl- adder contraction function.It has some value to verdict the happing of gallstone.2.Gallbladder's contraction function of depressed group declines.3.The increasing of the preprandial gallbladder's cubage and the degree of ΔVIP has connection with the information of gallstone. 4.CCK facilitates gallbladder to contract and restrain the formation of gallstone.5.The decrease of CCK-R makes gallbladder's contraction function weaken and facilitate the formation of gallstone.6.VIP restrains gallbladder's contraction and facilitates the formation of gallstone.