The Curative Effect Experimentation Of Treating New Zealand White Rabbits With DHF By The YiQiShuXin Granular Medicine(the Chinese Medicine)

Background: Diastolic heart failure (DHF) is a clinical syndrome characterized by the symptoms and signs of heart failure, a preserved ejection fraction (EF>45%), and abnormal diastolic function. From a conceptual perspective, diastolic heart failure occurs when the ventricular chamber is unable to accept an adequate volume of blood during diastole, at normal diastolic pressures and at volumes sufficient to maintain an appropriate stroke volume. These abnormalities are caused by a decrease in ventricular relaxation and/or an increase in ventricular stiffness and give rise to the left ventricular filling pressure elevating, the left ventricular filling capacity decreasing, systemic and pulmonary circulation congesting goring. It has been proofed that 35% to 40% of all the patients with heart failure are the DHF by reviewing the hospitalized patients in the 80's 20th century .The treatment of DHF is most experiencing and still short of large scale multiplicity centers random control clinical trial now. Therefore the diagnosis and treatment of the DHF is a most important project which is urgent to resolved in the fields of cardiology.Objective: This test is to systematically study the effective of the YiQiShuXin granular medicine in treating DHF of the rabbit and to enucleate what is it's probability functionary mechanism. Methods: The model of the rabbit DHF is established by feeding the New Zealand white rabbit 12 weeks with Cholesterol-Rich fodder. Treating groups are treated with the YiQiShuXin granular medicine(Chinese medicine with the effective of YiQiXuanfeiHuoxueLiShui), while control groups are treated with Cardizen and Captopril for 8 weeks. Such parameters as the left ventricle diastolic pressure (LVDP), contractility index and the left ventricle pressure (LVP) etc, are tested by the eight leads electricity physiology instrument (Japan, RW-6000) to evaluate the curative effect of the YiQiShuXin granular medicine on the DHF treatment. Results and Conclusions:1: The model of the rabbit DHF is successfully established by feeding the New Zealand white rabbit 12 weeks with Cholesterol-Rich fodder.2: The YiQiShuXin granular medicine can cut down the peak descending maximal rate in period of isovolumic contraction (-dp/dtmax), the left ventricle pressure (LVP), the left ventricle end diastole pressure (LVEDP), diastolic pressure (DBP), the level of the ET, XT, ANP, CHO, LDL-C and TG in blood.3: Such parameters as CHO, LDL-C, TG, ET and LVSP for the YiQiShuXin granular medicineare superior to Cardizen and Captopril, while its curative effect of is parallel with that of Cardizenand Captopril.4: The main mechanism is probably to obstruct the calcium ion passageway, decrease calcium overload inner the myocardium cell and cut down the blood grease and come back chaotic nerve endocritic level in some extent, particularly blood ET, AT and ANP, therefore stop further the development of DHF .