Experimental Research Of Dahuang Huanglian Xiexin Decoction Effects On Lipids And Ischemia Reperfusion Injury

Dahuang huanglian xiexin originated from Synopsis of Prescriptions of the Golden Chamber is thought as classical effects of clearing heat and poison, eliminating phlegm for relieving turbid pathogens, and removing heat from the blood to stop bleeding. In clinic it is used for treatment of unconsolidation of the heart-qi, hematemesis and nose-bleeding. There are no report about its effects on regulation piasma lipoprotein against atherosclerosis and cerebral ischemia reperfusion injury yet.With a dramatic changes of life style and diet structure in our nation today, the preference to the food fat and sweet leads to symptoms of stagnation of phlegm and damp-heat with high blood-fat, blood pressure and body mass index. Also there is a high incidence of disease in AS and cardio-cerebral syndrome. Take rats as the subject in the experiment with the method of clearing heat and poison. The model rats of hyperlipidemia are reproduced by high cholestrerol food. On this basis we wonder if the Decoction has effects on rats' lipoprotein metabolim. It turns out that the decoction can effectively reduce levels of serum cholesterol, triglyceride, low-density lipoprotein and oxidiged LDL. It can increase high-density lipoprotein's as well to prevent the occurrence and development of AS.Ischemic cerebral apoplexy belongs to "apoplexy" in TCM characterized by death, disability and high recurrence rate. It is also the first death cause of middle-aged and elderly people in our nation. The patients of AS have pathological re-construction in blood vessel and narrow lumen easy to form thrombus. If the thrombus can be perfusion within 3 to 6 hours, the patients will have a light commemorative sign. But the patients usually delay the opportunity of treatment resulting in ischemia and reperfusion injury. The latter causing oxidative stress, activing inducible NOS(iNOS) and proteinase Caspase. Which isthe major cause of neuron delayed death. The Decoction can obviously reduce injured rats' blood serum and cerebral the content of MDA and NO. But it can increase cerebral super-oxide dismutase; reduce cerebral NOS activity and down regutation the Caspase-3 expression. As the results to reduce ischemia perfusion injury.