The Expression And Clinical Significance Of Survivin, Fas/Fasl And P53 In Lung Carcinoma

Objective To investigate the expression and clinical significance of Survivin, Fas/FasL and P53 in human lung carcinoma.Methods The expressions of Survivin, Fas/FasL and P53 were detected in 59 cases of lung carcinoma and 14 cases of adjacent non-neoplastic tissues and 16 cases of lung benignant lesion tissues by PV-9000 immunohistochemical technique.Results The positive rate of Survivin in lung carcinoma (76.27%) was significantly higher than that in the normal lung tissues nearby (14.29%, P < 0..01) and in the benignant tissues (12. 5%, P<0. 01) ; No relation was found among the expression of Survivin and clinicopathologic factors including sex, age, tumor size, histoclassification, histological differentiation degree, . lymph node metastasis and TNM stage of lung carcinoma. The positive rate of Fas in lung carcinoma (44. 07%) was significantly lower than that in the normal lung tissues nearby (78.57%, P < 0.05) and in the benignant tissues (81.25%, p<0.01); No relation was found among the expression of Fas and clinicopathologic factors including sex, age, tumor size, histoclassification, histological differentiation degree, lymph node metastasis and TNM stage of lung carcinoma. The positive rate of FasL in lung carcinoma (69.49%) was significantly higher than that in the normal lung tissues nearby (7. 14%, P < 0. 01) and in the benignant tissues (12. 5%, P<0. 01) ; No relation was found among the expression of FasL and clinicopathologic factors including sex, age, tumor size, histoclassification, histological differentiation degree and TNM stage of lung carcinoma; The expression ofFasL was higher in patients with lymph node metastasis than in that without lymph node metastasis. The positive rate of P53 in lung carcinoma (64. 41%) was significantly higher than that in the normal lung tissues nearby (14. 29%, P<0. 01) and in the benignant tissues (23. 08%, P<0. 01) ; No relation was found among the expression of P53 and clinicopathologic factors including sex, age, tumor size, histoclassification, histological differentiation degree, lymph node metastasis and TNM stage of lung carcinoma. The expression of Survivin correlated with P53 (P<0.05). There was a significant negative relation between the expression of Fas and FasL in lung carcinoma.Conclusion The results suggested that Survivin and P53 might play synergetic roles in the process of cancinogenesis of lung carcinoma, and Survivin and P53 may be identified as a potential therapeutic target in lung carcinoma. The expression of Fas protein in lung carcinoma was low, and might play a role in carcinogenesis of lung carcinoma. The expression of Fas/FasL in lung carcinoma may play an important role in the escape of tumor cells from immune function. The expression of FasL might be used as an objective indicator of metastasis potency of local lymph node and FasL is worthy of further research in metastasis of lung carcinoma.