The Study Of TNFα,IL-6 In Type 2 Diabetes Mellitus And Diabetic Neuropathies

Background.Diabetes Mellitus (DM) is one of the diseases that threaten people's health. It is its chronic complications not others that affects the DM patients and their families, even the whole society. Of the complications, Diabetic Neuropathy(DNP) is the most common one. It is estimated that the prevalence of neuropathy in diabetes patients is approximately 50%-80%. Diabetic neuropathy affects sensory, autonomic, and motor neurons of the peripheral nervous system, which is to say that nearly every type of nerve fiber in the body is vulnerable. Moreover, every organ system in the body that relies on innervation for function is consequently subject to pathology. Therefore, diabetic neuropathy describes a number of unique syndromes that are primarily classified by the nerve fibers affected. As for the diseasecourse, it is fortunate that only a minority of patients experience neuropathic pain but tragic that a majority do not report symptoms until the complications are severe or irreversible.Recently study showed that subclinical chronic inflammation may be correlated with insulin resistance, which develop DM. It have been proved that some inflammatory cytokines, such as, TNF- (Tumor Necrosis factor alpha) IL-6 (lnterleukin-6), can affect blood sugar (BS) and due to DM. PGE1 ( prostaglandin EI ) is needed for regulating nerve conduction velocity(NCV) and microcirculation. Furthermore, it can dilate the distal blood vessel, increase blood fluid, restrain blood platelet collecting, and expedite NCV. ObjectiveTo discuss the expression of serum TNF IL-6 in DM and DNP group. To study the mechanism of PGE1 in DNP.MethodsAccording to the 1997 ADA criteria for DM diagnosis, 40 T2DM admitted in our hospital were accepted, were given DM food, exercise, oral drugs or insulin to control blood sugar. Among them, 20 were diagnosed as Diabetic Neuropathy. And 20 health people were accepted from the health care center in our hospital. Furthermore, the DNP group were acceptedPGE1 20pg qdxIOdays. Compare serum TNFcu IL-6 between the 3groups.The data was dealt with SPSS 11 .0 for statistics. Results1 . The data in 3 groups are comparable.2. Serum TNFa level was significantly higher in the DNP and DM groups than the control group ( p<0.01) . There was also significantly difference between the DM and DNP groups(p<0.05) .3. Serum IL-6 level was higher in the DNP group than the other two groups (p<0.05) . But there was no significantly difference between the DM and DNP groups (p>0.05) .4. For PGEi treatment .although the patients complained there were better turn in their condition, the level of TNF a and IL-6 had no change between before and after therapy.DiscussionThis research shows the TNF a , IL-6 had effect in the diabetes and diabetes nerve pathological changes. But the TNF a and IL-6 level were not parallel with the symptoms amelioration.