The Expression Of HSP70,p27,bcl-2 Protein And Clinical Significance In Non-small Cell Lung Cancer

Objective :To explore the clinical significance and expression of HSP70,p27,bcl-2 protein in Non-small cell lung cancer.Method: Immunohistochemistry was applied to detect the expression of HSP70,p27,bcl-2 protein in sixty cases of NSCLC and twenty tumor-surrounding normal lung tissues. The results were analysed and compared.Results: Campared with the tumor-surrounding normal tissues, the higher expression of HSP70,bcl-2 protein (respectively81.67%,73.33%)and the lower expression of p27 protein(21.67%) in NSCLC were observed, Their expression was distinctly different(P＜0.05).The expression of HSP70,p27,bcl-2 protein in squamous cell carcinomas and adenocarcinomas was not distinctly different, and not related with tumor size,differential degree,histology. but p27 was related with the metastasis by lymph, which the expression was obviously lower than the normal controls; The expression of bcl-2 protein was related with TNM stage,the stage Ⅰ-Ⅱ was significantly higer than the stage Ⅲ-Ⅳ.HSP70 was not correlated to metastasis and TNM.The expression of HSP70 protein was related with bcl-2 protein, but was not related with p27 protein in NSCLC.Conclusion: HSP70,p27,bcl-2 protein with controlling cytokine have a important influence in the NSCLC development, HSP70 and bcl-2 protein maybe improve tumorigenesis, on the contrary, p27 protein play a inhibitor role. p27 and bcl-2 protein expression are related with TNM; HSP70 and bcl-2 protein expression is positive correlation, inferring them together to strengthen NSCLC transformation; Therefore, the assay of those index may help diagnosis of NSCLC, and to find out mechanism ivolved, that will pave the way of the application of them on the biologic therapy of NSCLC.