The Relativity Study Of Thrombopoetin And The Counts Of Platelet And Megakaryocyte In Thrombocytopenia

Objective: To explore the relationship between thrombopoietin (TPO) levels and blood platelet count (BPC), megakaryocyte count in patients with thrombocytopenia and provide theoretical basis of clinical application of rhTPO.Methods: We measured blood platelet count, megakaryocyte count and the serum level of TPO in three group patients of differential diagnosis of thrombocytopenia . we classified patients as follows: (a), bone marrow aplasia group (n=21); (b). hypersplenism group (n=19); (c). idiopathic thrombocytopenic purpura (ITP, n=26).Results: The serum level of TPO was (85.12 ± 24.77) pg /ml in 26 normal controls. Compared with controls, the serum TPO levels in 13 aplastic anemia (AA) patients and 8 acute myelogenous lenkemia (AML) patients ( 345.92 ± 151.93 ) pg /ml and 26 idiopathic thrombocytopenic purpura (ITP) patients (179.40 ± 102.55) pg /ml were increasedsignificantly ( p < 0.05 ), in 19 patients with hypersplenism ( 97.74 ± 20.76 ) pg /ml was no significant difference ( p > 0.05) . The serum level of TPO in the patients with AA or AML was negative correlation with platelet counts ( r = -0.64352, p < 0.01) . The serum levels of TPO in the patients with hypersplenism and ITP were not correlation with platelet counts ( r = - 0.02648, -0.02831, p > 0.05) .Conclusion: The TPO levels differ from the causes of disease. The serum TPO level test could be useful in differentiation of the cause of thrombocytopenia and application of TPO according to different purposes .