| Objective To investigate the expression of MUC1, E-cad and β-cat protein on the evolution of gastric mucosa atypical hyperplasia, and the clinical value of this change in predicting gastric mucosa carcinomatous change; to investigate the clinical value of combined detection of MUC1, E-cad and p-cat protein expression on the diagnosis of gastric carcinoma, and in predicting prognosi of gastric carcinoma. Method Follow-up bioptic endoscopy was scheduled on the patients with atypical hyperplasia of gastric mucosa (n=74), the prognosi follow-up was scheduled on the patients with gastric cancer(n=60). MUC1, E-cad and P-cat protein expression of gastric mucosa were examined immunohistochemically, and its clinical-pathologic significance were analysised on the patients with gastric mucosa atypical hyperplasia or gastric cancer. Results (1)The detection rate of gastric mucosa atypical hyperplasia between 1991 and 2000 was 2.4% in our study. The expression rate of MUC1, E-cad and P-cat have significant discrepancy among the low, moderate and high atypical hyperplasia (P<0.05). Single-variate analysis indicated that MUC1, E-cad, β-cat and the atypical hyperplasia grade were related to carcinomatous change of gastric mucosa atypical hyperplasia. Multivariate analysis indicated that the atypical hyperplasia grade was the most important prognostic factors. (2)The expression rate of MUC1. E-cad and β-cat were relate to the clinicopathologic factors in gastric carcinoma. The expression rate of them all had significant discrepancy on different tumor stage, the tumor differentiation and whether the tumor had lymph nodes metastasis or not (P<0.05).Single-variate analysis indicated that the factors including the tumor stage, the tumor differentiation, with orwithout lymph nodes metastasis, the depth of tumor infiltration, the expression of MUCl, E-cad and β-cat, were all related to the 5 years survival rate in post-operation of gastric cancer. Multivariate analysis indicated that only the expression of MUCl was the most important prognostic factors. Conclusion (1)Surveillance of MUCl, E-cad and P-cat expression of gastric mucosa may help to prognosis the evolution of gastric mucosa atypical hyperplasia. (2)Surveillance of MUCl, E-cad and p-cat expression in gastric mucosa may contribute to the early diagnosis on the gastric carcinoma, and to judge the tumor stage, the tumor differentiation and whether the tumor have lymph nodes metastasis or not. |
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