Observation On The Effect And Mechanism Of Secondary Osteoporosis In Children Treated With Vitamin K

Objective Osteoporosis is presence frequently in much disease, which not only holds back the recovery,bone growth and development of children but also make a lot of troubles in the treatment. Although the osteoporosis in adults has been cared and studied allover the world as a health problem for a long time, a lot of enigma need to be discovered, let alone the osteoporosis in children, little of which has been learned so far, many problems such as causes, development and treatment need to be searched further more. Our research is to explore the characterization of the osteoporosis in children comparing with the adults, and to find an effective treatment plan for children osteoporosis so as to avoid the fracture with osteoporosis and ensure the recovery of patients smooth and steady. This research is an important complement and improvement in the field of osteoporosis study, and is a basis for studying the effect of the children osteoporosis for the individual development and lately adult osteoporosis further.Methods 1. This investigation was based on the results of animal model experiments and adult osteoporosis research. The patients with osteoporosis caused by nephropathy or glucocorticoid were grouped according to vitamin K administration, vitamin D administration and both administration in random. The markers of bone metabolism in blood and bone density were observed before and after the treatment, the side effect and the reaction among these factors were also considered in detail to analyze the action and mechanism of vitamin K. 2. Vitamin K or/and Vitamin D was administered to patients with disuse osteoporosis. The bone formation markers in blood and bone density was measured before and after treatment. The same measurements were performed in the patients with one extremity immobilization. The results were analyzed by comparing the before and after treatment or between the two sides to define the action of vitamin K in such patients.Results 1. Only 1 month after high-does steroid administration the serum osteocalcin and bone specific alkaline phosphatase dropping , and changes of bone density could be measured in the children with nephropathy osteoporosis. All of the changes had been proved significant in statistic. While in the patients treated with vitamin K all of three indexes ameliorated significantly comparing with pretreatment. osteocalcin and bone specific alkaline phosphatase in the blood have a positive correlation with the bone density. 2. The osteocalcin, bone specific alkaline phosphatase and bone density changed evidently in statistics after vitamin K administeration in patients with disuse osteoporosis. The time of fracture healing shortened could not be confirmed.Conclusions The children secondary osteoporosis is a latency menace in the recovery of children with the disease which can lead to osteoporosis. More attention should be paid to this. Vitamin K can relieve the extent of children osteoporosis with lesser does and shorter time comparing with the adult osteoporosis. Vitamin K and vitamin D can promote each other. Osteocalcin can be regard as a bone formation index in children just as bone specific alkaline phosphatase. Vitamin K is a safe, effective and simple drug and should be used widely researched further.