The Relationship Between The Concentration Of Glycosaminoglycan In Synovial Fluid And The Injury-degree Of Articular Cartilage

Objective To study the relationship between the concentration of glycosaminoglycan in synovial fluid and the injury-degree of articular cartilage, and discuss the feasibility of the glycosaminoglycan as a marker to diagnose the osteoarthritis(OA) at early stage. Methode 74 patients(age range: 15-70,mean age 39)who had been injured in single knee before 2 monthes, now they have not any inflammations. GAG concentrations were analyzed in joint fluid samples which were taken before operation of arthoendoscopy. The injury-degree of articular cartilage were graded and recorded under arthoendoscopy. Result In all samples, GAG concentrations of patients have relationship withthe injury-degree of articular cartilage increased (rs=0.553,P<0.05) when the grade under 10. Conclusion The changes of GAG concentrations with the injury-degree of cartilage may be used to evaluate the injury-degree of articular cartilage when the grade under 10. And, we maybe can use it to predict the development of disease and to appraise the curative eifect of treatment.