The Relationship Between Intrahepatic Cholestasis Of Pregnancy And Graft-versus Host Disease

Objective To explore effect of the fetal lymphocyte on pathogenesis of intrahepatic cholestasis of pregnancy (ICP) and relationship between ICP and graft-versus -host disease(GVHD) on etiology by comparision ICP with GVHD on pathogenesis since they have similar clinic manifestations.Methods 20 pregnant women with ICP and 20 normal pregnancy women were enrolled in the study.The Singal Mixed Lymphocyte Culture/Reaction, (MLC/MLR) was conducted using inactive peripheral blood mononuclear (PBMC) obtained from maternal peripheral blood and cord blood from fetus. And Antigen- induced- lymphocyte- proliferation- reaction was used dermic soluble antigen and decidual solube antigen obtained from maternal peripheral blood and cord blood from fetus.The intense of proliferation was calculated and compared between normal and ICP-complicated pregnancies. Result (1) The level of intense of proliferation of fetal lymphocyte was significantly increased in ICP group than those of normal control group in Singal Mixed Lymphocyte Culture. (2) The level of intense of proliferation of fetal lymphocyte was significantlyincreased in ICP group than those of normal control group in dermic soluble antigen induced lymphocyte proliferation reaction.(3) The level of intense of proliferation of fetal lymphocyte was significantly increased hi ICP group than those of normal control group in decidual soluble antigen induced lymphocyte proliferation reaction. Conclusions (1) The fetal lymphocyte may be one of the effective cells on pathogenesis of ICP. (2) And ICP and GVHD may have something in common on pathogenesis. (3) The disturbance of fatal-maternal immune-tolerance is one of the important mechanisms in ICP.