Influence Of Ketamine On Rapid Tracheal Intubating Conditions After Administration Of Propofol And Rocuronium

Objective To observe the effects of ketamine on rapid tracheal intubation after administration of propofol and rocuronium,fmd a reasonable induction of anaesthesia to improve the intubating conditions through investigating if ketamine can improve the intubating conditions one minute after administration of propofol and rocuronium.Methods 49 adult patients, without any neuromuscular disease and taking drugs known to interfere with neuromuscular transmission and who were scheduled to undergo elective surgery under general anaesthesia, were divided randomly to 2 groups: group K and group C. Anaesthesia was induced with fentanyl 2μg/kg, either ketamine 1mg/kg (group K) or saline 5ml (group C), propofol 2mg/kg and rocuronium 0.6mg/kg. One minute after rocuronium administration,tracheal intubation was performed and the intubating condition was assessed by a skilled anaesthetist blinded to group the choice of induction agent. Compared the onset time, the hemodynamic parameters during intubation and the incidence and severity of pain on propofol injection.Results The onset time of rocuronium was shorter in group K than in group C(51±7.8s vs 83±12s,P<0.05). The condition of intubation was more excellent in group K than in group C(P<0.05), but the condition of intubation considered to beclinically acceptable were similar in both groups.The heamodynamics in group K were more stable than in group C(P<0.05). The incidence and severity of pain on propofol injection in group K were less than in group C(P<0.05).Conclusion Ketamine can improve the intubating condition and stabilization of hemodynamics after propofol and rocuronium administration, and reduces incidence and severity of pain associated with propofol injection.