The Relationships Among Psychotic Symptoms, Cognition And The Results Of Protonmagnetic Resonance Spectroscopy (～1HMRS) Of Hippocampus And Prefrontal Cortex In Patients Of Schizophrenia

Objective: To discuss the relationships among psychotic symptoms, cognitive functions and the results of multi-voxel protonmagnetic resonance spectroscopy of hippocampus and prefrontal cortex in patients of schizophrenia. Methods: 17 patients meeting the criterion of CCMD-3 and ICD-10 for schizophrenia were assessed psychotic symptoms with the rating scale of PANSS and valued cognitive functions by 9 neuropsychological tests and checked Neurological Soft Signs(NSS). These patients were scanned by brain MRI and 2D PROBE/SI PRESS on a 1.5T MR system. The ROI were in hippocampus and prefrontal cortex. Signals from N-acetylaspartate (NAA), Creatine(Cr) and Choline(Cho) of hippocampus and prefrontal cortex. These ratios of NAA/Cr, Cho/NAA, Cho/Cr were computed. Compared these ratios of NAA/Cr, Cho/NAA, Cho/Cr between the predominant negative symptom group and the predominant positive symptom group and between different sex groups; Correlated among psychotic symptoms, cognition and NSS, and these metabolite ratios. Results: The lower ratio of NAA/Cr and the higher ratio of Cho/NAA of right dorsolateral prefrontal cortex were observed in the predominant negative symptoms patients than in the predominant positive symptoms patients; The difference of NAA/Cr of prefrontal cortex and the difference of NAA/Cr of dorsolateral prefrontal cortex were caused by the difference of negative symptom scores, not by male or female ;Only information had positive correlations with NAA/Cr of dorsolateral prefrontal cortex; The subscales of PANSS had no correlations with these ratios; Different psychotic symptoms had correlations with different cognitive functions, but some cognitive functions have no correlation with any psychotic symptoms. Conclusions: The prominent negative symptoms patients of schizophrenia have lower NAA of right dorsolateral prefrontal cortex than the prominent positive symptoms patients, but we could not to conclude the relationships of the lower NAA with psychotic symptoms in patients of schizophrenia; Cognitive functions may be the independent symptoms in schizophrenia, but the relationship with the metabolite ratios need to be studied further.