The Change Of Thyroid Hormones And Clinical Significance In Patients With Respiratory Failure

Object: To compare measurements of thyroid function and blood gas analysis between patients with acute and chronic respiratory failure. The purpose of this study was to investigate the relation between thyroid hormones and PaO2, PaCO2. Methods : Retrospective, observational study at the medical/intensive care unit(ICU) in our hospital, 70 patient were admitted in the study. Immediately, we took blood sample for EGA without inhaled oxygen at admission, and at 8:00 hours on the subsequent day, we took blood samples for measuring serum total (TT4) and free thyroxine (FT4), total (TT3) and free tri-iodothyroxine(FT3), thyrotropin (TSH)concentrations. Results: The value of FT3, TT3,TT4 in patients with respiratory failure were showed obviously lower than control group, there were no difference between acute and chronic groups. In acute group, FT4 was lower than control group, but hadn't difference between chronic and control groups. No differ among the three groups serum TSH existed. PaO2 did not differ in two groups, PaCO2 weresignificantly more in chronic RF group than acute RF group. PaO2 in patient with acute and chronic RF had positive relation with TT3, PaCO2 in the patients with chronic RF had a negative relation with FT3 TT3CP<0.05). TT4 and TSH in the patients with HF had no relation to PaO2 and PaCO2 (P>0.05). Conclusion: l.In patients with RF SES take place, 2.SES seems to related to the decrease of PaO2 and increase PaCO2; statistically significant positive relation between TT3 and PaO2 in patients, negative correlation between FT3) TT3 and PaCO2 in chronic RF. The fact suggests to measuring thyroid hormones concentration is useful, it can evaluate the state of illness in patients with RF.