| Objective: To investigate the role of Connexin43 in the development of human epithelial ovarian neoplasms. Methods: Paraffin -embedded tissue sections of 10 cases of normal ovarian epithelium and 38 cases of Serous ovarian tumor (8 cases of serous cystadenoma , 6 cases of borderline Serous cystadenoma , 24 cases of different differentiated Serous cystadenocatcinoma ) were involved in this study, Immunohisto chemistry were performed to detect the expression of cx43. The expression levels were quantified by image analysis. Results: In normal ovarian surface epithelia cells and tumor cells, CX43 in serous cystadenoma had no significant difference (p>0.05), But the expression levels of CX43 in borderline serous cystadenoma and serous cystadenocarcinoma were significantly lower (p<0.05; p<0.01). Furthermore, the expression of CX43 was significantly reduced as cancel cells became morphologically less differentiated (p<0.01).Conclusion: The data suggest that CX43 might has nothing to do with the development of benign ovarian tumor and that low expression of CX43 might play an important role in ovarian tumorigenesis. |
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