Clinical Value Of ～(131)I-MIBG Scintigraphy In Diagnosing Hypercatecholaminemia

To evaluate clinical value of 131I-MIBG adrenomedullary scintigraphy in diagnosing catecholaminemia. [Methods]For 59 patients with clinical findings suggestive of catecholaminemia, the results of imaging procedures, i.e. 131I meta-iodobenzylguanidine (MIBG) scintigraphy, computed tomography(CT), magnetic resonance imaging(MRI) and ultrasonography(USG) were reviewed. We laied stress on 131I MIBG scintigraphy . The final diagnosis of 24 patients with catecholaminemia were confirmed by operation and pathologic examination ; 10 of 35 cases without catecholaminemia were confirmed by operation , the other 25 cases without catecholaminemia were confirmed by clinical diagnosis. This is a retrospective comparison study. [Results]1. The diagnostic sensitivity, specificity and accuracy for catecholaminemia of 131I-MIBG scintigraphy was 95.8 %, 82.9%, 88.1%,respectively , sensitivity for pheochromocytoma (PHEO) was 100 %, sensitivity for adrenal medullary hyperplasia (AMH) was 92.3%.2. The diagnostic sensitivity, specificity and accuracy for catecholaminemia of CT was 80.0%, 77.8%, 78.9% , respectively; USG was 72.7%, 87.5%, 78.9% , respectively; MRI was 80.0%, 60.0%, 70.0% , respectively. The diagnostic sensitivity for PHEO of CT was 71.4%, USG was 50.0%, MRI was 50.0%. The diagnostic sensitivity for AMH of CT was 83.3%, USG was 81.8%, MRI was 50.0%.3. Between 131I-MIBG scintigraphy and CT, MRI, USG, there was no obvious statistical difference (P>0.05) in sensitivity, specificity and accuracy for diagnosing catecholaminemia and AMH. Between 131I-MIBG scintigraphy and CT, MRI , there was no obvious statistical difference(P>0.05) in sensitivity for diagnosing PHEO. Between 131I-MIBG scintigraphy and USG, there was obvious statistical difference (P<0.05) in sensitivity for diagnosing AMH.4. The rate of characteristic diagnosis for catecholaminemia correctly of 131I-MIBG scintigraphy, CT, MRI and USG was 23/24 (95.8%), 10/20 (50.0%) ,7/22 (31.8%) ,0/6 (0%).[Conclusion]131I-MIBG scintigraphy is the same valuable in diagnosing catecholaminemia as CT, MRI and USG , but 131I-MIBG is super than CT, MRI and USG in characteristic diagnosis for catecholaminemia.