The Experimental Study Of Early Pulmonary Injury Following Combined Powder Explosive And Burn Injury In Rats | Posted on:2003-10-20 | Degree:Master | Type:Thesis | Country:China | Candidate:R S Yu | Full Text:PDF | GTID:2144360092970009 | Subject:Surgery | Abstract/Summary: | PDF Full Text Request | Objective: To investigate the early pulmonar}' injury of rats fOHowing combinedpowder explosive and burn in jmp and its possible pathogenesis.Metbods: 96 Wstar rats were randomly divided into four groups which u'ere normalcontrol group (n=6). bum group (n=30). powder explosive group (n=30) and combinedpowder explosive-bum grouP (n=30). The latter three grouPs were more dit.ided into l.3. 6, l2. 24 hour post in jmp grouP. and in each sub grouP. the animal number is 6. Thelatter three grouPs were subjected to 20% total body suthee area full thickness burnin jmp ligh or moderate degree pulmoneq powder explosive in jun' and combinedpowder explosive-bum injUry respectively. The following of each group were examinedand studied' the water contents of the lung. the MDA. TNF- o contents and MPOactivities in the lung; the nuxnber of WBC- PAM and PMN in the BALF. the general.histological and ultrastructural pulmonan' pathology changes. and the relationshipbetween the number of PAM and PMN in the BALF with all other subjects.Results: Compared with normal control grouP. bum group and powder explosi\*e group.the combined powder explosive-bum group's level of water contents of the lung. MDA.TNF- Q contents and MPO activities in the lung- number of WBC. PAM. and PMN inthe BALF were all elevated significanly, and the general. histological andultraStrUtutal pulmonary pathology changes u-ere more severit}.. In the relationshipbetween the nurnber of PAM and PMN in the BALF with all other subjects. only thenumber of PAM had no relations with the lung MDA contents. the others t"ere allrelated.JCouclusions: The severity of ratS' pulmomp injwr would be aggrat.ated after thecombined powder explosive and bum injUry compared with single injury. It was aPOssible pathogenesis of combined powder explosive-burn injury that PAM wasactivated first. and then it generate the assemble and activation of PMN in the lung b}'direct or indirect way the latter would release a lot of cytokines. oxygen free radicalsand other toxic substances. resulting in tissue injury... | Keywords/Search Tags: | Powder, Explosive wounding, Burn, Combined injury, Pulmonary injury | PDF Full Text Request | Related items |
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